{"id":222541,"date":"2026-10-14T03:08:00","date_gmt":"2026-10-14T00:08:00","guid":{"rendered":"https:\/\/buletin.de\/bucuresti\/?p=222541"},"modified":"2026-10-13T23:26:35","modified_gmt":"2026-10-13T20:26:35","slug":"ce-mai-face-institutul-cantacuzino-din-bucuresti-studiaza-un-medicament-nou-impotriva-meningitei","status":"publish","type":"post","link":"https:\/\/buletin.de\/bucuresti\/ce-mai-face-institutul-cantacuzino-din-bucuresti-studiaza-un-medicament-nou-impotriva-meningitei\/","title":{"rendered":"Ce mai face Institutul Cantacuzino din Bucure\u0219ti: studiaz\u0103 un medicament nou \u00eempotriva meningitei. Rezultatele sunt \u00eencurajatoare"},"content":{"rendered":"\n<p class=\"wp-block-paragraph\"><strong>O substan\u021b\u0103 nou\u0103, numit\u0103 \u00een termeni \u0219tiin\u021bifici peptid\u0103 antimicrobian\u0103, ar putea duce la apari\u021bia unui medicament nou \u0219i revolu\u021bionar \u00eempotriva meningitei, o infec\u021bie grav\u0103 a creierului, care \u00een prezent este de multe ori mortal\u0103, arat\u0103 un studiu interna\u021bional, la care a participat \u0219i Institutul Cantacuzino din Bucure\u0219ti.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studiul \u201e<a href=\"https:\/\/www.nature.com\/articles\/s41598-026-71703-y?utm=scidigest\" target=\"_blank\" rel=\"noreferrer noopener\">Dezvoltarea unei noi peptide antimicrobiene chimere pentru tratamentul infec\u021biilor bacteriene ale sistemului nervos central<\/a>\u201d, publicat \u00een revista Scientific Reports, men\u021bioneaz\u0103 c\u0103 \u00een experimentele efectuate pe \u0219oareci infecta\u021bi cu bacteria care provoac\u0103 meningita, noua substan\u021b\u0103 a salvat aproximativ dou\u0103 treimi dintre animale (67%), fa\u021b\u0103 de jum\u0103tate (50%) \u00een cazul unui antibiotic folosit pentru compara\u021bie.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Cercet\u0103torii au legat un amestec de peptide cu efect antibacterian de o peptid\u0103 care \u201eghideaz\u0103\u201d molecula spre bariera creierului, printr-un conector chimic, \u0219i a ob\u021binut compusul P-FK5-X-TGN. A reu\u0219it, astfel, s\u0103 sparg\u0103 aceast\u0103 barier\u0103, care blocheaz\u0103 \u00een prezent majoritatea antibioticelor.<\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201eTratamentul infec\u021biilor sistemului nervos central (SNC) r\u0103m\u00e2ne o provocare clinic\u0103 major\u0103 din cauza naturii restrictive a barierei hematoencefalice (BHE), care limiteaz\u0103 sever administrarea majorit\u0103\u021bii agen\u021bilor antimicrobieni c\u0103tre \u021besutul cerebral infectat. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cen acest studiu, prezent\u0103m proiectarea ra\u021bional\u0103 \u0219i evaluarea unei peptide antimicrobiene chimere destinate s\u0103 traverseze BHE, P-FK5-X-TGN, care integreaz\u0103 un amestec puternic de peptide antimicrobiene aleatorii cu o peptid\u0103 de orientare c\u0103tre BHE, pentru a permite tratarea eficient\u0103 a meningitei bacteriene.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studiile in vitro realizate folosind un model multicelular al BHE au ar\u0103tat c\u0103 P-FK5-X-TGN a traversat bariera \u00een mod eficient \u0219i \u0219i-a p\u0103strat activitatea bactericid\u0103 \u00eempotriva N. meningitidis, \u00een timp ce peptida P-FK5 neconjugat\u0103 a prezentat o penetrare minim\u0103 a BHE, \u00een ciuda faptului c\u0103 avea o activitate antimicrobian\u0103 identic\u0103\u201d, arat\u0103 experimentele coordonate de Institutul Cantacuzino, \u00een afiliere cu Facultatea de Medicin\u0103 Veterinar\u0103 din cadrul USAMV Bucure\u0219ti.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Au mai participat cercet\u0103tori din Israel \u0219i Slovacia: Universitatea Ebraic\u0103 din Ierusalim, Universitatea de Medicin\u0103 Veterinar\u0103 \u0219i Farmacie din Ko\u0161ice (Slovacia) \u0219i Institutul de Neuroimunologie al Academiei Slovace de \u0218tiin\u021be. Corespondentul studiului este Zvi Hayouka, de la Universitatea Ebraic\u0103. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>CITE\u0218TE \u0218I: <a href=\"https:\/\/buletin.de\/bucuresti\/s-a-lansat-muzeul-viu-al-bucurestiului-fara-cladire-si-fara-bilet-de-intrare-68-de-locuri-din-capitala-reunite-intr-o-harta-digitala\/\" target=\"_blank\" rel=\"noreferrer noopener\">S-a lansat Muzeul Viu al Bucure\u0219tiului, f\u0103r\u0103 cl\u0103dire \u0219i f\u0103r\u0103 bilet de intrare. 68 de locuri din Capital\u0103, reunite \u00eentr-o hart\u0103 digital\u0103<\/a><\/strong><\/p>\n\n\n\n<h2 id=\"h-suntem-totu\u0219i-departe-de-un-medicament-nou-impotriva-meningitei\" class=\"wp-block-heading\">Suntem, totu\u0219i, departe de un medicament nou \u00eempotriva meningitei<\/h2>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Oamenii de \u0219tiin\u021b\u0103 men\u021bioneaz\u0103 c\u0103, \u00een ciuda faptului c\u0103 au ob\u021binut rezultate bune pe \u0219oareci \u0219i \u00een laborator, mai sunt mul\u021bi pa\u0219i de f\u0103cut p\u00e2n\u0103 la un medicament nou pentru meningit\u0103. <\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u201eP-FK5-X-TGN reprezint\u0103 o terapie promi\u021b\u0103toare de tip &#8216;dovad\u0103 de concept&#8217; pentru tratamentul meningitei bacteriene \u0219i, poten\u021bial, al altor infec\u021bii neuroinvazive. Prin combinarea eficacit\u0103\u021bii antimicrobiene cu transportul \u021bintit prin BHE, aceast\u0103 peptid\u0103 chimeric\u0103 r\u0103spunde unei nevoi critice nesatisf\u0103cute \u00een terapia infec\u021biilor SNC.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Studiile viitoare se vor concentra pe optimizarea proiect\u0103rii peptidei, elucidarea mecanismelor moleculare care stau la baza transloc\u0103rii prin BHE \u0219i evaluarea eficacit\u0103\u021bii \u00eempotriva altor agen\u021bi patogeni neurotropi. <\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cen ansamblu, aceast\u0103 lucrare stabile\u0219te peptidele antimicrobiene \u021bintite c\u0103tre BHE ca o nou\u0103 platform\u0103 pentru tratamentul infec\u021biilor SNC\u201d, arat\u0103 documentul.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>Meningita bacterian\u0103 este o infec\u021bie a sistemului nervos central cu mortalitate ridicat\u0103, iar tratamentul este greu pentru c\u0103 majoritatea antimicrobienelor trec cu greu de bariera hematoencefalic\u0103, men\u021bioneaz\u0103 <a href=\"https:\/\/www.nature.com\/articles\/s41598-026-71703-y\" target=\"_blank\" rel=\"noreferrer noopener\">rezumatul studiului<\/a>. <\/strong><\/p>\n\n\n\n<p class=\"wp-block-paragraph\">\u00cent\u00e2i, cercet\u0103torii au verificat \u00een laborator dac\u0103 substan\u021ba mai omoar\u0103 bacteria care provoac\u0103 meningita, dup\u0103 ce i s-a ata\u0219at \u201eghidul\u201d care o duce spre creier. A omor\u00e2t-o: a fost suficient\u0103 o cantitate foarte mic\u0103, de 8 microgame pe mililitru.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Apoi au \u00eencercat-o pe un model de laborator care imit\u0103 bariera de protec\u021bie a creierului. Acolo, substan\u021ba a reu\u0219it s\u0103 treac\u0103 \u0219i a distrus mai multe bacterii dec\u00e2t aceea\u0219i substan\u021b\u0103 f\u0103r\u0103 \u201eghid\u201d \u0219i dec\u00e2t un antibiotic folosit pentru compara\u021bie.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\">Apoi au testat-o pe \u0219oareci infecta\u021bi. Animalele au suportat-o bine, iar dou\u0103 treimi (67%) au supravie\u021buit, fa\u021b\u0103 de niciunul dintre cele tratate doar cu substan\u021ba f\u0103r\u0103 \u201eghid\u201d \u0219i jum\u0103tate dintre cele tratate cu antibioticul. Substan\u021ba a fost dat\u0103 \u00eentr-o doz\u0103 de cinci ori mai mic\u0103, dar num\u0103rul bacteriilor a sc\u0103zut de circa 1.000 de ori.<\/p>\n\n\n\n<p class=\"wp-block-paragraph\"><strong>CITE\u0218TE \u0218I: <a href=\"https:\/\/buletin.de\/bucuresti\/cele-mai-cautate-licee-din-bucuresti-ce-medii-au-avut-in-2026-si-ce-trebuie-sa-stii-inainte-de-evaluarea-nationala-2027-p\/\" target=\"_blank\" rel=\"noreferrer noopener\">Cele mai c\u0103utate licee din Bucure\u0219ti: ce medii au avut \u00een 2026 \u0219i ce trebuie s\u0103 \u0219tii \u00eenainte de Evaluarea Na\u021bional\u0103 2027 (P)<\/a><\/strong><\/p>\n","protected":false},"excerpt":{"rendered":"<p>O substan\u021b\u0103 nou\u0103, numit\u0103 \u00een termeni \u0219tiin\u021bifici peptid\u0103 antimicrobian\u0103, ar putea duce la apari\u021bia unui medicament nou \u0219i revolu\u021bionar \u00eempotriva meningitei, o infec\u021bie grav\u0103 a creierului, care \u00een prezent este de multe ori mortal\u0103, arat\u0103 un studiu interna\u021bional, la care a participat \u0219i Institutul Cantacuzino din Bucure\u0219ti. Studiul \u201eDezvoltarea unei noi peptide antimicrobiene chimere pentru [&hellip;]<\/p>\n","protected":false},"author":60,"featured_media":222724,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"ngg_post_thumbnail":0,"footnotes":"","_ppma_block_editor_authors":"{\"authors\":[22582],\"author_categories\":{\"22582\":\"1\"},\"fallback_author_user\":\"1\",\"ppma_author_box_select\":\"\",\"selected_authors\":[{\"id\":22582,\"display_name\":\"R\u0103zvan Chiru\u021b\u0103\",\"is_guest\":0,\"category_id\":\"1\"}]}"},"categories":[6994,5762,4],"tags":[2043,31547,31548],"ppma_author":[22582],"class_list":["post-222541","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-stiri-2","category-main","category-sanatate","tag-cantacuzino","tag-impotriva-meningitei","tag-medicament-nou"],"acf":[],"a3_pvc":{"activated":false,"total_views":0,"today_views":0},"yoast_head":"<!-- This site is optimized with the Yoast SEO Premium plugin v28.0 (Yoast SEO v28.6) - https:\/\/yoast.com\/product\/yoast-seo-premium-wordpress\/ -->\n<title>Ce mai face Institutul Cantacuzino din Bucure\u0219ti: studiaz\u0103 un medicament nou \u00eempotriva meningitei. 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