{"id":112223,"date":"2024-12-26T13:35:20","date_gmt":"2024-12-26T10:35:20","guid":{"rendered":"https:\/\/buletin.de\/bucuresti\/?p=112223"},"modified":"2024-12-26T13:44:42","modified_gmt":"2024-12-26T10:44:42","slug":"cercetari-pentru-noi-antibiotice-realizate-la-bucuresti","status":"publish","type":"post","link":"https:\/\/buletin.de\/bucuresti\/cercetari-pentru-noi-antibiotice-realizate-la-bucuresti\/","title":{"rendered":"Cercet\u0103ri pentru noi antibiotice, realizate la Bucure\u0219ti, \u00eempotriva microbilor rezisten\u021bi la tratamentele actuale"},"content":{"rendered":"\n

Cercet\u0103ri pentru noi antibiotice se desf\u0103\u0219oar\u0103 la Institutul Na\u021bional de Cercetare-Dezvoltare Chimico-Farmaceutic\u0103 (ICCF) din Bucure\u0219ti. Miza este combaterea microorganismele rezistente la tratamentele existente.<\/strong><\/p>\n\n\n\n

Ace\u0219tia analizeaz\u0103 proteinele FeS, molecule esen\u021biale pentru via\u021b\u0103, formate din clustere de fier-sulf, care joac\u0103 un rol crucial \u00een procesele celulare precum respira\u021bia \u0219i sinteza ADN-ului, potrivit revistei Ministerului Cercet\u0103rii, Inov\u0103rii \u015fi Digitaliz\u0103rii.<\/a><\/p>\n\n\n\n

\u201ePrin izolarea \u0219i purificarea acestor proteine din bacterii \u0219i utilizarea simul\u0103rilor moleculare, cercet\u0103torii proiecteaz\u0103 molecule cu poten\u021bial antibiotic, oferind solu\u021bii inovatoare pentru rezisten\u021ba la antimicrobiene, una dintre cele mai mari provoc\u0103ri globale de s\u0103n\u0103tate.<\/p>\n\n\n\n

Prevenirea \u0219i combaterea rezisten\u021bei la antibiotice necesit\u0103 strategii integrate care includ reducerea consumului inutil de antibiotice, educarea publicului \u0219i a profesioni\u0219tilor din domeniul s\u0103n\u0103t\u0103\u021bii, dar \u0219i investi\u021bii \u00een cercetare pentru a dezvolta noi medicamente \u0219i alternative terapeutice\u201d, men\u021bioneaz\u0103 cercet\u0103torii ICCF.<\/p>\n\n\n\n

CITE\u0218TE \u0218I: Retrospectiva Verde | Lupte pentru protejarea spa\u0163iilor verzi din Capital\u0103, \u00een 2024<\/a><\/strong><\/p>\n\n\n\n

Proteine cu rol vital \u00een existen\u021ba microorganismelor<\/h2>\n\n\n\n

Totodat\u0103, monitorizarea \u0219i controlul strict al utiliz\u0103rii antibioticelor \u00een toate domeniile sunt esen\u021biale pentru a preveni r\u0103sp\u00e2ndirea microorganismelor rezistente.<\/strong><\/p>\n\n\n\n

\u201e\u00cen acest context, proiectul Proiectarea \u0219i screeningul unor molecule de inactivare a proteinelor FeS \u2013 \u021binte moleculare la microorganisme antibiotic – rezistente, din cadrul Programului Nucleu Cercet\u0103ri multidisciplinare avansate pentru identificarea \u0219i caracterizarea de produse \u015fi tehnologii inovative alternative, cu aplicabilitate \u00een \u015ftiin\u0163ele vie\u0163ii, al Institutului Na\u0163ional de Cercetare-Dezvoltare Chimico-Farmaceutic\u0103 – ICCF Bucure\u015fti, se \u00eencadreaz\u0103 unei politici publice la nivel european de combatere a infec\u021biilor cu agen\u021bi patogeni rezisten\u021bi.<\/p>\n\n\n\n

Obiectivul acestui proiect \u00eel reprezint\u0103 cercetarea \u0219i descoperirea unor noi antibiotice ca alternative terapeutice, \u00een cadrul planului de ac\u021biune european O singur\u0103 s\u0103n\u0103tate (One Health) \u00eempotriva rezisten\u021bei la antimicrobiene (RAM), lansat de Parlamentul European \u00een septembrie 2018 \u0219i Strategiei farmaceutice pentru Europa, lansat\u0103 de Comisia European\u0103 \u00een noiembrie 2020, destinate unei provoc\u0103ri majore pentru s\u0103n\u0103tatea public\u0103, reprezentat\u0103 de microorganismele rezistente la antibiotice\u201d, precizeaz\u0103 Ministerul Cercet\u0103rii, Inov\u0103rii \u015fi Digitaliz\u0103rii.<\/p>\n\n\n\n

Studiate \u00een ultimele dou\u0103 decenii, proteinelor con\u021bin\u00e2nd clusterul fier-sulf, prezente \u00een aproape toate organismele vii, li se acord\u0103 o aten\u021bie deosebit\u0103 \u00een ultimii ani, pe m\u0103sura noilor descoperiri privind rolul acestora \u00een procesele celulare \u0219i rela\u021bia lor cu terapia.<\/strong><\/p>\n\n\n\n

\u201eAv\u00e2nd un rol vital \u00een existen\u021ba microorganismelor, aceste proteine pot deveni \u021binte terapeutice de elec\u021bie \u00een terapie, prin inhibarea lor cu molecule ligand ca poten\u021biale antibiotice, realiz\u00e2nduse moartea celular\u0103.<\/p>\n\n\n\n

De\u0219i se recunoa\u0219te aceast\u0103 posibilitate, studiile publicate \u00een aceast\u0103 direc\u021bie sunt foarte pu\u021bine, iar cele referitoare la izolarea \u0219i purificarea proteinelor microbiene FeS se refer\u0103 la molecule recombinante ob\u021binute prin inginerie genetic\u0103 \u0219i care nu apar\u021bin unor microorganisme antibiotic-rezistente.<\/p>\n\n\n\n

Proiectul ICCF \u00ee\u0219i asum\u0103 o provocare \u0219i o ac\u021biune temerar\u0103, de a izola, a purifica aceste proteine \u0219i de a proiecta molecule ligand pentru combaterea unor microorganisme s\u0103lbatice multirezistente, cunosc\u00e2nd dificult\u0103\u021bile recunoscute \u00een izolarea \u0219i purificarea acestora\u201d, men\u021bioneaz\u0103 \u0219i cercet\u0103torii ICCF.<\/p>\n\n\n\n

CITE\u0218TE \u0218I: Bucure\u0219ti | Peste 26 milioane lei au dat prim\u0103riile c\u0103tre biserici, \u00een 2024. Cu c\u00e2t a contribuit fiecare sector<\/a><\/strong><\/p>\n\n\n\n

Cercet\u0103ri pentru noi antibiotice. Colaborare cu spitalul de boli infec\u021bioase Bucure\u0219ti<\/h2>\n\n\n\n

Prin colaborare cu Spitalul Clinic de Boli Infec\u021bioase \u0219i Tropicale \u201eDr. Victor Babe\u0219\u201d, s-au ob\u021binut, din colec\u021bia acestuia, primele tulpini de microorganisme antibiotic-multiplu rezistente, recomandate ca importan\u021b\u0103 clinic\u0103 \u0219i anume: Stapylococcus aureus MRSA (GT4853), izolat\u0103 din hemocultur\u0103, rezistent\u0103 la opt antibiotice, \u0219i Escherichia coli ESBL (GV0739), rezistent\u0103 la nou\u0103 antibiotice.<\/strong><\/p>\n\n\n\n

\u201eS-au efectuat studii de sintez\u0103 biologic\u0103 a proteinelor FeS de c\u0103tre microorganisme, de identificare a acestor proteine \u00een solu\u021biile ob\u021binute \u0219i se studiaz\u0103 purificarea lor. \u00cen paralel, s-au efectuat studii de proiectare molecular\u0103 in silico, const\u00e2nd \u00een caracterizarea cuantic\u0103 a unor molecule model con\u021bin\u00e2nd grup\u0103ri (clustere) FeS \u0219i de proiectare a unor molecule ligand.<\/p>\n\n\n\n

Se utilizeaz\u0103 algoritmi de calcul hibrizi DFT (Density Functional Theory) pentru calculul propriet\u0103\u021bilor \u0219i simul\u0103ri de andocare molecular\u0103 pentru evaluarea afinit\u0103\u021bii fa\u021b\u0103 de proteinele \u021bint\u0103\u201d, precizeaz\u0103 ace\u0219tia, potrivit publica\u021bie In House, a Ministerului Cercet\u0103rii, Inov\u0103rii \u0219i Digitaliz\u0103rii.<\/p>\n\n\n\n

Rezisten\u021ba la antibiotice r\u0103m\u00e2ne una dintre cele mai mari provoc\u0103ri pentru s\u0103n\u0103tatea global\u0103 \u00een secolul XXI, iar colaborarea interna\u021bional\u0103 \u0219i responsabilitatea fiec\u0103rui individ sunt esen\u021biale pentru a opri aceast\u0103 criz\u0103 \u00een expansiune.<\/strong><\/p>\n\n\n\n

Sursa: \u0218tiin\u021b\u0103 \u0219i comunicare<\/strong><\/a><\/p>\n","protected":false},"excerpt":{"rendered":"

Cercet\u0103ri pentru noi antibiotice se desf\u0103\u0219oar\u0103 la Institutul Na\u021bional de Cercetare-Dezvoltare Chimico-Farmaceutic\u0103 (ICCF) din Bucure\u0219ti. Miza este combaterea microorganismele rezistente la tratamentele existente. Ace\u0219tia analizeaz\u0103 proteinele FeS, molecule esen\u021biale pentru via\u021b\u0103, formate din clustere de fier-sulf, care joac\u0103 un rol crucial \u00een procesele celulare precum respira\u021bia \u0219i sinteza ADN-ului, potrivit revistei Ministerului Cercet\u0103rii, Inov\u0103rii \u015fi […]<\/p>\n","protected":false},"author":1,"featured_media":112225,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"_acf_changed":false,"inline_featured_image":false,"ngg_post_thumbnail":0,"footnotes":""},"categories":[6994,5762,4],"tags":[17917,17920,17918,17919],"ppma_author":[22583],"class_list":["post-112223","post","type-post","status-publish","format-standard","has-post-thumbnail","hentry","category-stiri-2","category-main","category-sanatate","tag-antibiotice","tag-cercetare-bucuresti","tag-cercetari-antibiotice","tag-chimico-farmaceutica"],"acf":[],"a3_pvc":{"activated":false,"total_views":0,"today_views":0},"yoast_head":"\nCercet\u0103ri pentru noi antibiotice, realizate la Bucure\u0219ti<\/title>\n<meta name=\"description\" content=\"Cercet\u0103ri pentru noi antibiotice se desf\u0103\u0219oar\u0103 la Institutul Na\u021bional de Cercetare-Dezvoltare Chimico-Farmaceutic\u0103 (ICCF) din Bucure\u0219ti.\" \/>\n<meta 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